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Unlike steroids and other illegal anabolics, there are not very many side effects associated with MK 677 use—at least the way I've heard it described. "Stomach pains, a slight sore throat, dry mouth, and perhaps some minor constipation could be related, but none too severe," wrote the researcher on the American Journal of Gastroenterology. The U.S. Food and Drug Administration's official advisory statement on amphetamines, which recommends testing a patient's urine for amphetamines if they suffer from a high, adds that "it is important to note that there are also many side effects of amphetamines that are not considered side effects of the treatment itself." These include "anxiety, restlessness, depression, lethargy, nervousness, restlessness, agitation, difficulty concentrating, and tremors. Ingestion of amphetamines may cause vomiting that can lead to dehydration." I spoke with Dr. David Kessler, President of ACSH about the long-term effects of long-term use of a drug like amphetamines, the nature of those side effects and how he might prescribe a patient if they've tried it. VICE: You've said that you saw all these symptoms associated with amphetamines for the most part after just a month or so off of taking them. Can you expand on that and why you think that long-term use leads to this? David Kessler: In the 1950s I saw first hand a patient who did three or four months of treatment with amphetamines and ended up with a severely depressed personality. In addition to that you also see an increase in anxiety, aggression—really the very behaviors they were seeking to treat and the medication is designed to control. You see the results of this treatment in terms of personality disorders and psychiatric illnesses. Kessler notes that the American Psychiatric Association has not established a "medically recognized disorder" that is associated with amphetamines; amphetamines appear to only provide mild "therapeutic" effects. How can you tell how much long-term amphetamine use is influencing a person's behaviors compared to just the usual, relatively short term use? Long-term use of amphetamines can increase these problems, because the body becomes accustomed to the medication and reacts to it with tolerance. The drug is there, but there's a higher level of action than is normal, and that makes the person more anxious or stressed. The drug also seems to give people a little more energy—the higher an amphetamine user gets, the more he seems to have an energy crisis Related Article: